Semaglutide (CAS 910463-68-2), is a 31-amino acid GLP-1 receptor agonist with a C18 fatty diacid linked to Lys34 via a mini-PEG-glutamic acid linker. It belongs to the lipid-acylated GLP-1 analogue chemical class. The main structural changes are the Aib8 substitution and the Arg34 → Lys34 modification, which make DPP-4 resistant and allow site-specific lipidation. The octadecanedioic acid (C18 diacid) – OEG-OEG-Glu linker (CAS 1118767-16-0) provides strong albumin binding (>99%), extending half-life to ~165 hours enabling once-weekly dosing. Trp25/Trp oxidation (major), deamidation at Gln/Asn, fatty acid chain truncation variants, deletion peptides, and SNAC (permeation enhancer) in Rybelsus are all examples of process impurities.
ApiSyn provides Semaglutide and all the important SPPS building blocks as pharmaceutical reference standards for GLP-1 quality control and analytics.
| Chemical Name | Glycine, L-histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl |
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.6 |
| CAS Number | 910463-68-2 |