Palm-L-Glu-OtBu 536721-25-2 Palm-L-Glu-OtBu (CAS 536721-25-2), also called N-palmitoyl-L-glutamic acid alpha-tert-butyl ester or Nα-palmitoyl-L-Glu(α-OtBu), is a N-acylated glutamic acid derivative of the fatty acid-acylated amino acid chemical class. The alpha-carboxyl group (OtBu-protected) is used to connect to more linker parts. This building block can also be used to make other acylated peptide drugs that need a palmitate-amino acid linker strategy. The C16 palmitic acid chain has a moderate lipophilicity (log P ~4.5), which helps it bind to albumin.
ApiSyn offers Palm-L-Glu-OtBu (CAS 536721-25-2) as a pharmaceutical-grade SPPS building block for the synthesis of liraglutide and related fatty acid-acylated GLP-1 peptides.
| Chemical Name | (S)-5-(tert-butoxy)-5-oxo-4-palmitamidopentanoic acid |
| Molecular Formula | C25H47NO5 |
| Molecular Weight | 441.7 |
| CAS Number | 536721-25-2 |