N-Formyl-3,5-dimethyladamantane-1-amine (CAS 351329-88-9), also known as N-formyl memantine or 1-(3,5-dimethyl-1-adamantyl)formamide, is a protected adamantylamine from the N-formyl-adamantane chemical class. This compound is the direct precursor (N-protected intermediate) in the synthesis of Memantine Hydrochloride. Residual N-formyl Memantine in the final API is a process-related impurity that must be identified and qualified according to ICH Q3A. The formamide NH is known for its unique restricted rotation (cis/trans rotamers) in 1H NMR, which shows up as two separate sets of signals at room temperature.
ApiSyn provides N-Formyl-3,5-dimethyladamantane-1-amine (CAS 351329-88-9) as a pharmaceutical-grade synthetic intermediate and process impurity reference standard for Memantine quality control and analytical method validation per ICH Q3A requirements.
| Chemical Name | N-(3,5-dimethyladamantan-1-yl)formamide |
| Molecular Formula | C13H21NO |
| Molecular Weight | 207.3 |
| CAS Number | 351329-88-9 |