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Mazdutide

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Mazdutide

(2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,62S)-35-(((8S,11S,14S,17S,20S,23S,26S,29S)-17-((1H-indol-3-yl)methyl)-1-((S)-2-(((S)-1-((2-amino-2-oxoethyl)amino)-3-hydroxy-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-26-benzyl-31-carboxy-8,20-bis(2-carboxyethyl)-11,14-diisobutyl-23-isopropyl-1,4,7,10,13,16,19,22,25,28-decaoxo-3,6,9,12,15,18,21,24,27-nonaazahentriacontan-29-yl)carbamoyl)-2-((2S,5S,8S,11S,17S,23S)-23-amino-17-(3-amino-3-oxopropyl)-8-benzyl-5,11-bis((R)-1-hydroxyethyl)-2-(hydroxymethyl)-24-(1H-imidazol-4-yl)-20,20-dimethyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-11,26,29-tris(4-aminobutyl)-23-(2-carboxyethyl)-20-(carboxymethyl)-5,14-bis(4-hydroxybenzyl)-8-(hydroxymethyl)-17-isobutyl-32-methyl-3,6,9,12,15,18,21,24,27,30,33,41,50,59,64-pentadecaoxo-43,46,52,55-tetraoxa-4,7,10,13,16,19,22,25,28,31,34,40,49,58,63-pentadecaazadooctacontane-1,62,82-tricarboxylic acid

2259884-03-0

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Mazdutide (CAS 2259884-03-0) is an investigational long-acting dual glucagon receptor (GCGR) and GLP-1 receptor agonist peptide in Phase 3 development for obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis (MASH). Mazdutide is a fatty acid-acylated GLP-1/GCG co-agonist peptide that has a structure similar to that of semaglutide and tirzepatide. It has been designed with the right amino acid substitutions to balance the activation of the GLP-1 and glucagon receptors. The glucagon part makes the suppression of glucose production in the liver and lipolysis/thermogenesis even stronger than just activating the GLP-1 receptor. This helps with NASH/MASH by using both anti-inflammatory and metabolic methods. SPPS manufacturing uses Fmoc chemistry and special side chain building blocks that are similar to semaglutide and tirzepatide. Deamidation (Asn/Gln), oxidation (Trp, Met), deletion sequences, and lipid-unconjugated impurity species are all examples of process-related impurities. 


ApiSyn sells Mazdutide (CAS 2259884-03-0) as a pharmaceutical reference standard to help the GLP-1/GCGR dual agonist space grow in obesity and MASH drug development.

Chemical Name (2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,62S)-35-(((8S,11S,14S,17S,20S,23S,26S,29S)-17-((1H-indol-3-yl)methyl)-1-((S)-2-(((S)-1-((2-amino-2-oxoethyl)amino)-3-hydroxy-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-26-benzyl-31-carboxy-8,20-bis(2-carboxyethyl)-11,14-diisobutyl-23-isopropyl-1,4,7,10,13,16,19,22,25,28-decaoxo-3,6,9,12,15,18,21,24,27-nonaazahentriacontan-29-yl)carbamoyl)-2-((2S,5S,8S,11S,17S,23S)-23-amino-17-(3-amino-3-oxopropyl)-8-benzyl-5,11-bis((R)-1-hydroxyethyl)-2-(hydroxymethyl)-24-(1H-imidazol-4-yl)-20,20-dimethyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-11,26,29-tris(4-aminobutyl)-23-(2-carboxyethyl)-20-(carboxymethyl)-5,14-bis(4-hydroxybenzyl)-8-(hydroxymethyl)-17-isobutyl-32-methyl-3,6,9,12,15,18,21,24,27,30,33,41,50,59,64-pentadecaoxo-43,46,52,55-tetraoxa-4,7,10,13,16,19,22,25,28,31,34,40,49,58,63-pentadecaazadooctacontane-1,62,82-tricarboxylic acid
Molecular Formula C207H317N45O65
Molecular Weight 4476.1
CAS Number 2259884-03-0
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