Lanreotide Acetate (CAS 127984-74-1) is a synthetic somatostatin analogue octapeptide from the cyclic disulfide-bridged somatostatin mimetic chemical class. The sequence is [cyclo(2-7)] H-D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2. It has D-2-naphthylalanine (D-2-Nal) at position 1, a Cys2–Cys7 disulfide bridge, and a C-terminal threonamide. Lanreotide is approved for acromegaly (first-line or after surgical failure), gastroenteropancreatic neuroendocrine tumors (GEP-NETs), and TSH-secreting pituitary adenomas. The D-2-Nal residue makes it harder for peptidase to cut through than Phe1 in native somatostatin. To make SPPS, you need a special Fmoc-D-2-Nal-OH building block (CAS 138774-94-4).
ApiSyn sells Lanreotide Acetate and specialty Fmoc amino acid building blocks (D-2-Nal, D-Trp) as pharmaceutical reference standards for quality control of somatostatin analogues.
| Chemical Name | (4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-19-((R)-2-amino-3-(naphthalen-2-yl)propanamido)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-10-(4-aminobutyl)-16-(4-hydroxybenzyl)-7-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide acetate |
| Molecular Formula | C54H69N11O10S2 : X(C2H4O2) |
| Molecular Weight | 1096.3 : X(60.1) |
| CAS Number | 127984-74-1 |