Fmoc-OIC-OH (CAS 130309-37-4), also known as Nα-Fmoc-(4R)-4-hydroxy-L-proline analog or Fmoc-L-octahydroindole-2-carboxylic acid (Oic), is a Fmoc-protected bicyclic proline analogue of the octahydroindole-2-carboxylic acid class. Oic is a pyrrolidine-fused cyclohexane amino acid that looks like proline but is much more rigid and hydrophobic than regular proline. The bicyclic structure of Oic keeps the cis-psi angle that is best for GnRH antagonist receptor binding in place. Fmoc-Oic-OH is a secondary amine like proline. The D-Tic isomer is the related compound Fmoc-D-(TIC)-OH (CAS 130309-33-0).
ApiSyn sells Fmoc-OIC-OH (CAS 130309-37-4) as a pharmaceutical-grade specialty constrained amino acid building block for making Degarelix and GnRH antagonist peptides.
| Chemical Name | (2S,3aS,7aS)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)octahydro-1H-indole-2-carboxylic acid |
| Molecular Formula | C24H25NO4 |
| Molecular Weight | 391.5 |
| CAS Number | 130309-37-4 |