Fmoc-Lys(Boc)-OH (CAS 71989-26-9), also known as Nα-Fmoc-Nε-Boc-L-lysine, is the standard doubly protected lysine for Fmoc-SPPS. It belongs to the Fmoc-lysine Boc epsilon-amino class. This is one of the most common Fmoc amino acids used to make pharmaceutical peptides. Boc protects the ε-amino group (TFA takes it off in global deprotection), and piperidine takes off the α-Fmoc at each SPPS cycle. Lysine is the acylation site in GLP-1 fatty acid-modified peptides (Liraglutide Lys26, Semaglutide Lys34, Tirzepatide Lys26, Retatrutide Lys24). After global TFA deprotection, the free ε-NH2 can be used to couple with a fatty acid side chain or make other changes.
ApiSyn sells Fmoc-Lys(Boc)-OH (CAS 71989-26-9) as a pharmaceutical-grade Fmoc amino acid building block and a critical raw material reference standard for making and testing the quality of GLP-1 peptide APIs.
| Chemical Name | N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysine |
| Molecular Formula | C26H32N2O6 |
| Molecular Weight | 468.6 |
| CAS Number | 71989-26-9 |