Fmoc-D-Aph(tBu,Cbm)-OH (CAS 1433975-21-3), also known as Nα-Fmoc-D-4-aminophenylalanine (N-tBu-carbamoyl), is a specialized Fmoc-protected D-aminophenylalanine derivative with a tBu-carbamoyl (Cbm) group on the para-amino position. It is part of the protected D-aminophenyl alanine Fmoc class. This compound is a special building block for making GnRH antagonists, especially for compounds like Ozarelix and related degarelix-type GnRH antagonist decapeptides, where modified D-Aph residues at positions 6 and/or 9 make the GnRH receptor antagonism very strong.
ApiSyn sells Fmoc-D-Aph(tBu,Cbm)-OH (CAS 1433975-21-3) as a pharmaceutical-grade specialty D-amino acid building block for making GnRH antagonist peptides, developing analytical methods, and making sure the quality of the product.
| Chemical Name | (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(3-(tert-butyl)ureido)phenyl)propanoic acid |
| Molecular Formula | C29H31N3O5 |
| Molecular Weight | 501.6 |
| CAS Number | 1433975-21-3 |