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Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo- 4,5,6,7-tetrahydro -1H-pyrazolo[3,4-c]pyridine-3-carboxylate (CAS 536759-91-8) is a nitro-substituted pyrazolopyridine ester that belongs to the tetrahydropyrazolopyridine chemical class. This compound is an important early-stage synthetic intermediate for making Apixaban. If the reduction is incomplete, residual nitro-compound can show up as a process-related impurity in Apixaban API. This means that it needs to be qualified according to ICH Q3A. Since it is a genotoxic structural alert intermediate, it also needs to be risk assessed according to ICH M7 guidelines for mutagenic impurities.
ApiSyn offers this Apixaban nitro-intermediate (CAS 536759-91-8), ICH M7 mutagenic impurity testing, and Apixaban impurity profiling.
| Chemical Name | Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate |
| Molecular Formula | C22H20N4O6 |
| Molecular Weight | 436.4 |
| CAS Number | 536759-91-8 |