C20-OtBu-Glu(OtBu)-AEEA-OH (CAS 2645421-68-5) is a partially protected fatty acid-amino acid-PEG linker fragment. It is made up of eicosanedioic acid (C20 diacid, tBu-protected) linked to L-glutamic acid (γ-tBu ester) and then to a single AEEA (8-amino-3,6-dioxaoctanoic acid) unit with a free carboxylic acid terminus. It belongs to the C20 fatty diacid-Glu-AEEA linker building block class. It connects the C20 fatty acid anchor to one AEEA hydrophilic spacer. The free carboxylic acid at the end of the AEEA chain can connect to another AEEA unit (to make the bis-AEEA tirzepatide linker) or directly to the Fmoc-Lys building block.
ApiSyn offers C20-OtBu-Glu(OtBu)-AEEA-OH (CAS 2645421-68-5) as a pharmaceutical-grade specialty building block for the synthesis and quality control of Tirzepatide and next-generation incretin peptide side chains.
| Chemical Name | (S)-13-(tert-butoxycarbonyl)-36,36-dimethyl-10,15,34-trioxo-3,6,35-trioxa-9,14-diazaheptatriacontanoic acid |
| Molecular Formula | C39H72N2O10 |
| Molecular Weight | 729 |
| CAS Number | 2645421-68-5 |