Product Details

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran (CAS 915095-89-5) is a chiral bromochlorophenyl-phenoxytetrahydrofuran ether that belongs to the halogenated aryl diaryl ether tetrahydrofuran chemical class. This enantiomerically pure (3S) compound is an advanced-stage synthetic intermediate in the synthesis of Dapagliflozin. The chiral tetrahydrofuranyl ether brings in the stereochemically defined oxygen-bridged ring that will eventually be part of the final SGLT2 inhibitor scaffold. The THF ring gives the structure strength and directs the pharmacophore orientation at the SGLT2 transporter. The (3R)-enantiomer is the main enantiomeric impurity. 

ApiSyn offers (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran (CAS 915095-89-5) as a pharmaceutical-grade enantiopure intermediate and impurity reference standard for the development of the Dapagliflozin SGLT2 inhibitor process.