Product Details

3-Fluoro-4-morpholinoaniline 93246-53-8 3-Fluoro-4-morpholinoaniline (CAS 93246-53-8) is a fluorinated morpholinyl aniline in the fluorophenyl-morpholine amine chemical class. This compound is an important step in the industrial process of making Rivaroxaban, which is a direct Factor Xa inhibitor.The fluorine at the ortho position to the morpholine affects how the ring rotates, how many electrons are in it, and how stable it is in the body. As a primary aromatic amine (Ames-positive structural alert), it is an ICH M7 mutagenic impurity that needs to be evaluated for risk and may need to be qualified if it is above the TTC (threshold of toxicological concern) in the API. If it is above the identification threshold, residual aniline is also an ICH Q3A-qualified impurity. 

For the development and quality control of the Rivaroxaban API process, ApiSyn offers 3-Fluoro-4-morpholinoaniline (CAS 93246-53-8) as a high-purity pharmaceutical intermediate and ICH M7 mutagenic impurity reference standard.