Product Details

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile (CAS 207557-35-5), also known as N-chloroacetyl-L-proline nitrile or (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile, is a reactive N-chloroacetyl-protected pyrrolidine nitrile of the (S)-cyanopyrrolidine-chloroacetamide chemical class. This compound is the most important penultimate intermediate in the making of Vildagliptin, which is a DPP-4 inhibitor for type 2 diabetes. The alpha-halo amide is a bifunctional electrophile (ICH M7 genotoxic structural alert - alpha-haloamide) that needs a risk assessment. The residual amount in Vildagliptin API must be within TTC limits. The (S)-cyanopyrrolidine is the DPP-4 pharmacophore, and the (R)-enantiomer of this intermediate would be a very important stereoisomeric impurity. 

ApiSyn offers (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile (CAS 207557-35-5) as a pharmaceutical-grade chiral intermediate and ICH M7 mutagenic impurity reference standard for the development and quality control of Vildagliptin API.