1,1-Dimethylethyl N-(3R)-3-piperidinylcarbamate (CAS 309956-78-3), also known as (R)-3-(Boc-amino)piperidine or Boc-(R)-3-aminopiperidine, is a chirally pure N-Boc-protected (R)-3-aminopiperidine that belongs to the piperidine carbamate chemical class. This compound is a key enantiopure building block for making JAK inhibitors, because it has the (3R)-piperidinyl stereocenter that is needed for JAK1 selectivity. As a chiral amine intermediate, ICH Q3A and ICH Q6A require strict control of enantiomeric purity (≥99% ee by chiral HPLC).
ApiSyn provides Boc-(R)-3-aminopiperidine (CAS 309956-78-3) as a pharmaceutical-grade chiral intermediate for developing JAK inhibitors and as a standard for impurities in regulatory submissions.
| Chemical Name | Tert-butyl (R)-piperidin-3-ylcarbamate |
| Molecular Formula | C10H20N2O2 |
| Molecular Weight | 200.3 |
| CAS Number | 309956-78-3 |